1. 学術論文

Ouyang Zhiming, Kumar Manish, Kariu Toru, Haq Shayma, Goldberg Martin, Pal Utpal, Norgard Michael V.

BosR (BB0647) governs virulence expression in Borrelia burgdorferi.

Mol Microbiol. Vol.74:1331-43 (2009)

 

Yang Xiuli, Lenhart Tiffany R, Kariu Toru, Anguita Juan, Akins Darrin R, Pal Utpal.

Characterization of unique regions of Borrelia burgdorferi surface-located membrane protein 1.

Infect Immun. Vol.78:4477-87 (2010)

 

Kariu Toru, Coleman Adam S, Anderson John F, Pal Utpal.

Methods for rapid transfer and localization of lyme disease pathogens within the tick gut.

J Vis Exp. 14;48電子ジャーナル(2011)

 

Burbelo Peter D, Bren Kathleen E, Ching Kathryn H, Coleman Adam, Yang Xiuli, Kariu Toru, Iadarola Michael J, Pal Utpal.

Antibody Profiling of Borrelia burgdorferi Infection in Horses.

Clin Vaccine Immunol. Vol.18:1562-7 (2011)

 

Yang Xiuli, Promnares Kamoltip, Qin Jinhong, He Ming, Shroder Deborah Y, Kariu Toru, Wang Yan, Pal Utpal.

Characterization of Multiprotein Complexes of the Borrelia burgdorferi Outer Membrane Vesicles.

J Proteome Res. 10:4556-66 (2011)

 

Eggers Christian H, Caimano Melissa J, Malizia Robert A, Kariu Toru, Cusack Brian, Desrosiers Daniel C, Hazlett Karsten R, Claiborne Al, Pal Utpal, Radolf Justin D.

The coenzyme A disulfide reductase of Borreliaburgdorferiis important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host.

Mol Microbiol. 82:679-97 (2011)

 

Kumar Manish, Kaur Simorjot, Kariu Toru, Yang Xiuli, Bossis Ionasis, Anderson John F, Pal Utpal.

Borrelia burgdorferi BBA52 is a potential target for transmission blocking Lyme disease vaccine.

Vaccine 29:9012-9 (2011)

 

Ching Wooen Sze, Kai Zhang, Toru Kariu, Utpal Pal, and Chunhao Li

Borrelia burgdorferi needs chemotaxis to establish infection in mammals and to accomplish its enzootic cycle.

Innfect Immun. 80:2485-92 (2012)

 

Yang X, Qin J, Promnares K, Kariu T, Anderson JF, Pal U.

Novel microbial virulence factor triggers murine lyme arthritis.

J Infect Dis. 207(6):907-18 (2013)

 

Kariu T, Yang X, Marks CB, Zhang X, Pal U.

Proteolysis of BB0323 results in two polypeptides that impact physiologic and infectious phenotypes in Borrelia burgdorferi.

Mol Microbiol. 88(3):510-22 (2013)

 

Kariu T, Smith A, Yang X, Pal U.

A chitin deacetylase-like protein is a predominant constituent of tick peritrophic membrane that influences the persistence of Lyme disease pathogens within the vector.

PLoS One 17;8(10):e78376 (2013)

 

Kariu T, Sharma K, Singh P, Smith AA, Backstedt B, Buyuktanir O, Pal U.

BB0323 and novel virulence determinant BB0238: Borrelia burgdorferi proteins that interact with and stabilize each other and are critical for infectivity.

J Infect Dis. 2015 Feb 1;211(3):462-71

 

Imamura T, Yamamoto-Ibusuki M, Sueta A, Kubo 3, Irie A, Kikuchi K, Kariu T, Iwase H.

Influence of the C5a-C5a receptor system on breast cancer progression and patient prognosis.

Breast Cancer. (2015) in press

Kariu T, Nakao R, Ikeda T, Nakashima K, Potempa J, Imamura T.

 

Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids.

J Periodontal Res. 2017 Feb;52(1):89-96  

 

Toru Kariu,Tsuyoshi Ikeda,Keisuke Nakashima,Jan Potempa, Takahisa Imamura

A natural anti-periodontitis agent, epimedokoreanin B, inhibits virulence activities of gingipains from Porphyromonas gingivalis

Biosci Biotechnol Biochem. 2019 Jul;83(7):1382-1384 

 

Imamura R, Kitagawa S, Kubo T, Irie A, Kariu T, Yoneda M, Kamba T, Imamura T.

Prostate cancer C5a receptor expression and augmentation of cancer cell proliferation, invasion, and PD-L1 expression by C5a.

Prostate. 2021 Feb;81(3):147-156

 

2. 主要な学会発表

Toru Kariu, Xiuli Yang, Manish Kumar, Xynue Zhang, Adam Coleman, Brian Backstedt, Alexis Smith, and Utpal Pal

Analysis of Borrelia burgdorferi virulence factors using targeted gene disruption and microinjection into ticks

20th Seminar on Acari-Disease Interface 2012 in Anan、徳島　(2012)

 

狩生徹、西岡弘子、畑中千春、坂口修一、井上雄太郎、山本滋、岡正朗、水上洋一

次世代DNAシーケンサーSOLiD5500を用いた乳癌でのエストロゲン受容体を誘導する遺伝子変異の探索

第35回日本分子生物学会、福岡　(2013)

 

狩生 徹，Xiuli Yang，Manish Kumar，Xynue Zhang，Utpal Pal

ライム病菌Borrelia burgdorferi 感染因子BB0323の機能とその成熟機構

第87回日本細菌学会、東京　(2014) 招待ワークショップ

 

3. 外部資金獲得実績

2019-21 科研費　基盤研究(C)　ゴマ由来の歯周病抑制ペプチドの同定とその有効性解析　代表

2019-21 科研費　国際共同研究加速基金(A)　プレニル化フラボノイドは、歯周病が引き起こす全身疾患を抑制できるか？　代表

2017-18 JST　熊本復興支援(地域産学バリュープログラムタイプ)　熊本県産農産品に含まれるポリフェノール類の抗菌性に着目した新規機能性食品の開発　代表

2017 ＣＯＣ＋事業　特別プロジェクト経費　杖立温泉地域フードツーリズム支援プロジェクト　代表

2016 日本私立学校振興・共済事業団　学術研究振興資金　新規歯周病治療薬としてのイカリソウエキスの評価　代表

2016-18 科研費　基盤研究(C) 　プレニル化フラボノイドの新規歯周病治療薬としての有効性評価　代表  

2013-15 科研費　基盤研究(C) 　次世代DNAシーケンサーを用いた高悪性度乳がんを引き起こす新規体細胞変異の探索　代表

2008 科研費　若手研究(B)　ハブ毒による血液凝固阻害・血管障害の分子病態解析　代表　辞退

2007-08 科研費　若手研究(B)　ハブ毒に含まれる新規出血因子の作用機構等解析　代表

2006-07 科研費　基盤研究(C)　ハブ毒成分の毒腺組織特異的発現調節機構の解明　分担

2006-07 科研費　若手研究(スタートアップ)　アプタマーを用いた新規ハブ咬傷治療薬の開発 　代表

 

4. 教育

食べ物と健康　II．食品学各論　食品の分類・特性・利用　Visual栄養学テキスト　第３章分担執筆